July is sarcoma awareness month

Thomas Vu
Jul 01, 2025By Thomas Vu

For this month of July, we shine a spotlight on understanding sarcoma- a rare and aggressive form of cancer that originates from connective tissues such as bone, muscle, fat, and cartilage. Unlike the more common carcinomas, which arise from epithelial cells, sarcomas develop from mesenchymal cells and can manifest in nearly any part of the body. Due to their diverse subtypes and unpredictable behavior, sarcomas present a unique clinical challenge that necessitates a multidisciplinary approach for effective diagnosis and treatment. Sarcomas are generally categorized into two broad types: soft tissue sarcomas and bone sarcomas. Soft tissue sarcomas include a wide array of subtypes, such as liposarcoma, which arises from fat tissue; leiomyosarcoma, originating from smooth muscle; and angiosarcoma, which develops from blood vessels. Bone sarcomas are less common and include osteosarcoma, Ewing sarcoma, and chondrosarcoma, each derived from different elements of bone or cartilage tissue.

The precise causes of most sarcomas are not well understood, but several risk factors have been identified. These include genetic syndromes such as Li-Fraumeni syndrome and neurofibromatosis type 1, prior exposure to radiation therapy, chronic lymphedema, and contact with certain chemicals like vinyl chloride or herbicides. Clinically, sarcomas often present as painless, enlarging masses. The symptoms depend heavily on the tumor’s location. For instance, sarcomas in the limbs may appear as a swelling or a lump, whereas retroperitoneal sarcomas might cause vague abdominal discomfort or fullness due to the pressure on adjacent organs. Bone sarcomas frequently manifest with localized pain and swelling, symptoms that can easily be mistaken for musculoskeletal injury or growing pains in adolescents.

Diagnosis of sarcoma begins with imaging studies such as MRI to evaluate the local extent of soft tissue tumors and CT scans to check for metastasis, particularly in the lungs. Bone scans may be employed for skeletal involvement. A core needle biopsy is the preferred method for obtaining tissue samples, allowing for histological and molecular analysis to confirm the diagnosis and subtype of sarcoma. Histopathological examination is essential, as it not only identifies the specific type of sarcoma but also helps in determining the appropriate treatment strategy.

Treatment of sarcoma typically involves a combination of surgery, radiation therapy, and chemotherapy. Surgery remains the cornerstone of treatment, with the primary goal being the complete removal of the tumor with clear margins to minimize the risk of recurrence. Radiation therapy may be administered before or after surgery to improve local control. Chemotherapy is often reserved for high-grade or metastatic sarcomas and commonly involves agents such as doxorubicin and ifosfamide. In recent years, targeted therapies and immunotherapies have shown promise for certain subtypes, such as the use of imatinib for gastrointestinal stromal tumors.

The prognosis for patients with sarcoma depends on several factors, including tumor size, grade, location, depth, and the presence of metastases. High-grade tumors and those diagnosed at an advanced stage generally have a poorer outcome. Long-term follow-up is essential due to the risk of recurrence and late metastases. In conclusion, sarcomas represent a complex and diverse group of cancers that require early recognition and a coordinated treatment approach. With ongoing research and the development of novel therapies, there is hope for improved outcomes and quality of life for patients affected by this challenging disease.